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Author (up) Rajasingh, H; Gjuvsland, AB; Våge, DI; Omholt, SW doi  openurl
  Title When parameters in dynamic models become phenotypes:a case study on flesh pigmentation in the Chinook salmon (Oncorhynchus tshawytscha) Type Journal Article
  Year 2008 Publication Genetics Abbrev Journal Genetics  
  Volume 179 Issue Pages 1113-1118  
  Corporate Author Thesis  
  Address Norwegian University of Life Sciences.  
  Keywords  
  Abstract The Pacific Chinook salmon occurs as both white and red-fleshed populations, with the flesh color type (red or white) seemingly under strong genetic influence. Previously published data on crosses between red- and white-fleshed individuals cannot be reconciled with a simple Mendelian two-locus, two-allele model, pointing to either a more complex inheritance pattern or the existence of gene interactions. Here we show that a standard single locus, three-allele model can fully explain these data. Moreover, by implementing the single locus model at the parameter level of a previously developed mathematical model describing carotenoid dynamics in salmon, we show that variation at a single gene involved in the muscle uptake of carotenoids is able to explain the available data. This illustrates how such a combined approach can generate biological understanding that would not be possible in a classical population genetic explanatory structure. An additional asset of this approach is that by allowing parameters to become phenotypes obeying a given genetic model, biological interpretations of mechanisms involved at a resolution level far beyond what is built into the original dynamic model are made possible. These insights can in turn be exploited in experimental studies as well as in construction of more detailed models.  
  Publisher Place Editor  
  Language ENG Summary Language Orig Title  
  Series Editor Series Title Abbrev Series Title  
  Series Volume Series Issue Edition  
  Issn 0016-6731 Isbn Medium  
  Area Expedition Conference  
  Notes PUBMED: 18505867 Approved no  
  Location Arne Gjuvsland (arne.gjuvsland@umb.no)  
  Call Number Cigene @ arne.gjuvsland @ Serial 1328  
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