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Author  |
Olsen, H G; Meuwissen, T H E; Nilsen, H; Svendsen, M; Lien, S |
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Title |
Fine mapping of quantitative trait Loci on bovine chromosome 6 affecting calving difficulty |
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Journal Article |
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Year |
2008 |
Publication |
J Dairy Sci |
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Volume |
91 |
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11 |
Pages |
4312-22 |
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Address |
Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, N-1432 As, Norway. hanne-gro.olsen@umb.no |
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Keywords |
Animals; Cattle; Cattle Diseases; Chromosome Mapping; Chromosomes; Dystocia; Female; Linkage Disequilibrium; Pregnancy; Quantitative Trait Loci |
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Abstract |
Calving difficulty is an economically and ethically important trait for dairy cattle breeding. The aim of the present paper was to refine the position of a previously detected quantitative trait locus (QTL) affecting calving difficulty (direct effect) in Norwegian Red dairy cows. A granddaughter design consisting of 18 elite sire families and a total of 713 sons was genotyped for 154 markers spanning the QTL region, and the trait data were analyzed by using a combined linkage and linkage disequilibrium approach. A highly significant QTL was detected in a 150-kb interval between the markers LAP3_281 and BTA-114677. Additionally, there were some indications of a second QTL between the markers BTA-75776 and BTA-75780 located less than 500 kb apart. Several candidate genes may be identified close to these QTL. Of these, a cluster of genes expected to affect bone and cartilage formation may be of particular interest for follow-up studies. |
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Language |
eng |
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Issn |
1525-3198 |
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Notes |
PUBMED: 18946137 |
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no |
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Location |
Torfinn Nome (torfinn.nome@umb.no) |
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Call Number |
Cigene @ torfinn.nome @ |
Serial |
1549 |
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