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Author  |
Østby, I.; Øyehaug, L.; Einevoll, G.T.; Nagelhus, E.A.; Plahte, E.; Zeuthen, T.; Lloyd, C.M.; Ottersen, O.P.; Omholt, S.W. |
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Title |
Astrocytic Mechanisms Explaining Neural-Activity-Induced Shrinkage of Extraneuronal Space |
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Journal Article |
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Year |
2009 |
Publication |
PLoS Comput Biol |
Abbrev Journal |
PLoS Comput Biol |
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Volume |
5 |
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1 |
Pages |
e1000272- |
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Address |
entre for Integrative Genetics (CIGENE), Norwegian University of Life Sciences, Ås |
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Abstract |
<title>Author Summary</title> <p>A key experimental observation associated with the astroglia–neuron interaction is the shrinkage of the extracellular space (ECS) that occurs in response to enhanced neuronal activation. Although well documented to be present in mammalian brains, this phenomenon has resisted a proper explanation since it was first reported. We present here a mathematical conceptualization that may explain the main mechanisms behind ECS shrinkage and provide a framework for a theoretical-experimental research programme that may help to reach a consensus explanation. Effective clearance of K+ is essential for normal brain function because an inappropriate increase in extracellular K+ will enhance neuronal excitability and promote neuronal afterdischarges and increase the probability of epileptic episodes. The shrinkage of the ECS usually appears in conjunction with K+ clearance and must be taken into account in a model of how astrocytes clear excess K+ following trains of action potentials. The present model allows us to make several clear and testable predictions addressing the relationship among potassium clearance, water transport, and ECS shrinkage. Among these are predictions concerning water transport functions of aquaporins in astrocytes, involvement of cotransporters in potassium clearance, and effects of particular knockouts on ECS shrinkage and ion concentrations.</p> |
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Public Library of Science |
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no |
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Location |
Torfinn Nome (torfinn.nome@umb.no) |
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Call Number |
Cigene @ torfinn.nome @ |
Serial |
1558 |
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