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Author (up) Nilsen, H; Olsen, H G; Hayes, B; Nome, T; Sehested, E; Svendsen, M; Meuwissen, T H E; Lien, S    openurl
  Title Characterization of a QTL region affecting clinical mastitis and protein yield on BTA6 Type Journal Article
  Year 2009 Publication Anim Genet Abbrev Journal  
  Volume 40 Issue 5 Pages 701-12  
  Corporate Author Thesis  
  Address Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Box 5003, N-1432 Aas, Norway.  
  Keywords Animals; Cattle; Chromosome Mapping; Female; Genetic Markers; Haplotypes; Linkage Disequilibrium; Mastitis, Bovine; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Selection, Genetic  
  Abstract Quantitative trait loci affecting clinical mastitis were detected and fine mapped to a narrow region on bovine chromosome 6 in the Norwegian Red cattle population. The region includes the casein gene cluster and several candidate genes thought to influence clinical mastitis. The most significant results were found for SNPs within the Mucin 7 gene. This gene encodes an antimicrobial peptide and constitutes part of the first line of defence for the mucosal immune system. Detection of long haplotypes extending several Mb may indicate that artificial selection has influenced the haplotype structures in the region. A search for selection sweeps supports this observation and coincides with association results found both by single SNP and haplotype analyses. Our analyses identified haplotypes carrying quantitative trait loci alleles associated with high protein yield and simultaneously fewer incidences of clinical mastitis. The fact that such haplotypes are found in relative high frequencies in Norwegian Red may reflect the combined breeding goal that is characterized by selection for both milk production and disease resistance. The identification of these haplotypes raises the possibility of overcoming the unfavourable genetic correlation between these traits through haplotype-assisted selection.  
  Publisher Place Editor  
  Language eng Summary Language Orig Title  
  Series Editor Series Title Abbrev Series Title  
  Series Volume Series Issue Edition  
  Issn 1365-2052 Isbn Medium  
  Area Expedition Conference  
  Notes PUBMED: 19466933; Research Support, Non-U.S. Gov't Approved no  
  Location Barbara Eriksen (barbara.eriksen@umb.no)  
  Call Number Cigene @ barbara.eriksen @ Serial 1615  
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