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Author (up) Gjuvsland, Arne B; Hayes, Ben J; Omholt, Stig W; Carlborg, Orjan doi  openurl
  Title Statistical epistasis is a generic feature of gene regulatory networks Type Journal Article
  Year 2007 Publication Genetics Abbrev Journal Genetics  
  Volume 175 Issue 1 Pages 411-20  
  Corporate Author Thesis  
  Address Linnaeus Centre for Bioinformatics, Uppsala University, SE-751 24 Uppsala, Sweden.  
  Keywords  
  Abstract Functional dependencies between genes are a defining characteristic of gene networks underlying quantitative traits. However, recent studies show that the proportion of the genetic variation that can be attributed to statistical epistasis varies from almost zero to very high. It is thus of fundamental as well as instrumental importance to better understand whether different functional dependency patterns among polymorphic genes give rise to distinct statistical interaction patterns or not. Here we address this issue by combining a quantitative genetic model approach with genotype-phenotype models capable of translating allelic variation and regulatory principles into phenotypic variation at the level of gene expression. We show that gene regulatory networks with and without feedback motifs can exhibit a wide range of possible statistical genetic architectures with regard to both type of effect explaining phenotypic variance and number of apparent loci underlying the observed phenotypic effect. Although all motifs are capable of harboring significant interactions, positive feedback gives rise to higher amounts and more types of statistical epistasis. The results also suggest that the inclusion of statistical interaction terms in genetic models will increase the chance to detect additional QTL as well as functional dependencies between genetic loci over a broad range of regulatory regimes. This article illustrates how statistical genetic methods can fruitfully be combined with nonlinear systems dynamics to elucidate biological issues beyond reach of each methodology in isolation.  
  Publisher Place Editor  
  Language eng Summary Language Orig Title  
  Series Editor Series Title Abbrev Series Title  
  Series Volume Series Issue Edition  
  Issn 0016-6731 Isbn Medium  
  Area Expedition Conference  
  Notes PUBMED: 17028346 Approved no  
  Location Arne Gjuvsland (arne.gjuvsland@umb.no)  
  Call Number Cigene @ arne.gjuvsland @ Serial 702  
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